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Buy sildenafil online (Viagra, Revatio) is an affordable drug to treat erectile problems in men.

It is also to treat pulmonary arterial hypertension, severe heart and lung conditions.

For instance, his drug is more popular than comparable drugs. Available in regular and branded versions.

Viagra is a successful pill for the healing of premature climax. This drug is most pharmacies and is definitely a very good decision because if you want to buy. Buy viagra online on the Internet, you can buy cheap Viagra. Side effects Discomfort is a terrible point that affects many areas of human life.

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Therefore Common Viagra side effects may include: Flushing (warmth, redness, or tingling sensation). Buy sildenafil headache, dizziness; Abnormal vision (blurred vision, changes in color vision) runny nose or nasal congestion, nosebleeds. Sleep problems (insomnia);Muscle pain, back pain; Or. I had a stomach burn. This is not a complete list of side effects and other side effects may occur.

The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binder of PDE5. Therefore, in corpus cabernosum, resulting in more cGMP and increased penile response to sexual activity. Stimulation. In the absence of sexual stimulation, the lack of activation of the NO/cGMP. So, the system means that sildenafil should not cause an erection.

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Other drugs that work by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra). Sildenafil in the liver by cytochrome p450 enzyme, mainly by liver metabolism using CYP450 3A4 (main pathway). As well as by CYP2C9 (minor pathway) liver isoenzyme. The main product of metabolism by this enzyme is N-demethylat sildenafil, which is further metabolizes . Such metabolites also have an affinity for the PDE receptor, which is about 40% of sildenafil. Thus, the metabolite is responsible for about 20% of the action of sildenafil.

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Buy Sildenafil 100mg is mainly as a metabolite in feces (about 80% of the administered oral dose) and in the urine (about 13% of the administered oral dose). When taken with a high-fat meal, absorption decreases. The time it takes to reach the maximum plasma. The concentration increases by about an hour, and the maximum concentration itself decreases by almost a third of the time.


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